A recent study indicates that patients who stop using new weight-loss injections like semaglutide or tirzepatide may regain shed pounds much more quickly than those who stop traditional diet and exercise regimens.
Research printed in a major medical journal points out that while obese people can lose a large proportion of their body weight while undergoing treatment, the mass comes back at an estimated rate of 0.8 kg per month after stopping.
"Users using these drugs need to be informed of the potential of fast rebound weight gain when the treatment ends," warns researcher Dr. Susan Jebb.
Such speed of regain implies a return to pre-treatment mass in about one and a half years.
Analyzing Treatments
The analysis, which looked at dozens of studies involving thousands of patients, compared the effects of these new drugs with other pills.
Researchers note that people who shed pounds through dieting typically see a more gradual creep back—approximately 0.1 kg a month—after stopping.
Understanding the Fast Rebound
Doctors believe the way of the jabs is key to understanding the accelerated weight return.
The injections mimic a natural hormone called GLP-1, which helps regulate hunger.
"Sustained high doses of the hormone concentrations several times higher than normal could lead to the body to generate a reduced amount of its endogenous hormone, and could lessen sensitivity to its effects," noted Dr. Adam Collins, a nutrition specialist.
"Withdrawal of this hormone supplement means appetite is unsuppressed, making excessive eating much more probable."
An Ongoing Disease?
Health authorities recommend the jabs for people with weight-linked medical conditions, accompanied by recommended lifestyle changes.
A number of clinicians contend that, considering the significant potential of weight regain, the treatment might need to be long-term.
This perspective is echoed by drug manufacturers, who state that the findings "underscore the chronic character of excess weight," similar to managing diseases like diabetes.
Patient Testimonies
People who have stopped the jabs explain a sudden resurgence of cravings.
"It was like a trigger that goes on and you become starving," described a patient.
The struggle is worsened if users have not adopted lasting dietary or behavioural changes during therapy.
Significant Adoption
Recent estimates suggest that millions of people in the UK have used these injections in the past year, with interest being substantial.
- Use is greater among females compared to men.
- The middle-aged age group shows the greatest usage rates.
- Many obtain the medications through private prescriptions rather than public health services.
In conclusion, experts emphasize that while these medications are potent agents for shedding pounds, they are not a permanent solution and long-term success hinges on combined lifestyle support.